The study on the development of self-emulsifying compositions with simvastatin

Self-emulsifying compositions are the basis of oral drug delivery systems used to improve solubility and increase bioavailability active pharmaceutical ingredients that poorly soluble in aqueous medium gastric juice. Aim. To develop self-emulsifying using simvastatin as an ingredient. Materials methods. During development composition mixture, excipients, such solvents, co-solvents, surfactants co-surfactants, allowed production were used. The studies solubility, formation rate emulsions stability carried out by generally accepted methods according SPhU other valid normative documents. Results discussion. choosing a mixture castor oil PEG-40 GRO solvent, which improved substance oil. It was determined it efficient use Tween-80 main surfactant. Glycerol monostearate, distilled monoglycerides, polyethylene oxide-400, oxide-1500 glycol-100 stearate introduced into co-surfactants. found compositions, included oxide-400 oxide-1500, had significantly worse indicators than rest samples. sample containing monoglycerides did not withstand decrease pH value medium. Conclusions. According results obtained, samples oil, hydrogenated Tween-80, glycerol monostearate or PEG-100 selected for further research.